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Also, the finding that a CD8-specific T-cell response can be elicited in neoepitopes derived from Histidine Ammonia-Lyase (HAL), Neuraminidase 2 (NEU2), Proprotein Convertase Subtilisin (PCSK9), Programmed Cell Death 10 (PDCD10), Supervillin (SVIL) and tRNA Splicing Endonuclease Subunit 54 (TSEN54) variants is in line with the notion that specific T cell-mediated immunotherapy can be applied for MB (189)